Abstract
Use of proton pump inhibitor (PPI) is associated with parietal cell protrusions and oxyntic gland dilatations. It is generally accepted that PPI use develops fundic gland polyps by its effect on parietal cells. However, we often detect endoscopically two interesting mucosal changes in the patients with PPI use such as cobblestone like mucosa (CSM) and cracked mucosa (CM) of fundic gland area. The aim of this study was to clarify the relationship between PPI use and these mucosal changes.
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