Mo1551 DARPP-32 Proteins up-Regulate Angpt2 and Enhance Angiogenesis in Gastric Cancer

Abstract

G A A b st ra ct s as H. pylori status (74.0% H. pylori positive). Pairwise linked comparison of gene expression at the different sample sites did not reveal any difference of RACGAP1 gene expression between tumor, tumor adjacent and tumor-free distant mucosa (see table 1). For biopsy samples obtained from tumor tissue there was a positive correlation of gene expression of RACGAP1 with gene expression of both β-catenin and DKK2 (β-catenin: r=0.300; p=0.036; DKK2: r=0.373; p=0.008). This could be confirmed for intestinal type not for diffuse type GC (intestinal type: β-catenin: r=0.393; p=0.039; DKK2: r=0.401; p=0.035). There was also a positive correlation of gene expression of RACGAP1 and β-catenin in samples obtained from tumor adjacent tissue (r=0.463; p=0.001), which could be confirmed for both histological types (intestinal: r=0.388; p=0.038; diffuse: r=0.622; p=0.010). Conclusion: RACGAP1 is expressed in gastric adenocarcinoma. The positive correlation of RACGAP1 with β-catenin and DKK2 suggests a functional role as modulator of Wnt-dependent signaling in intestinal type gastric cancer. Gene expression of RACGAP1, β-catenin and DKK2 (mean +/SD in arbitrary units [a.u.])