Abstract
Fluid analysis of pancreatic cystic neoplasms (PCNs) using EUS-fine needle aspiration (EUS-FNA) are routinely performed to differentiate mucinous vs. non-mucinous cysts. Specificity of cytology in the diagnosis of malignant PCNs is high but its sensitivity is low. In cyst fluid analysis, a CEA of >192 ng/mL is one of the standard criteria for diagnosing mucinous cysts, but it is not useful for differentiating malignant lesions. Most PCNs including mucinous cysts undergo interval surveillance, including repeat EUS, but the role and significance of repeat fluid analysis is poorly defined in patients with PCNs under serial EUS.
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