Abstract
Although pain is a common complication of endoscopic submucosal dissection (ESD), management strategies are inadequate. Our prior research indicated that single-dose postoperative intravenous dexamethasone after ESD effectively relieved epigastric pain (Surg Endosc. 2014 Aug;28(8):2334-41). Transmission of pain signals evoked by tissue damage leads to sensitization of the peripheral and central pain pathways. Pre-emptive analgesia is a treatment that is initiated before the surgical procedure in order to reduce this sensitization.
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