MO150: Serum Angiopoietin-Like Protein 3 Level is Negatively Associated with Vascular Reactivity Index by Digital Thermal Monitoring in Chronic Haemodialysis Patients

Abstract

Abstract BACKGROUND AND AIMS Angiopoietin-like protein 3 (ANGPTL3) plays important roles in lipid and lipoprotein trafficking and metabolism and has demonstrated a positive correlation with cardiovascular risk assessment parameters of carotid and femoral artery intima-media thickness. We evaluated the association between serum ANGPTL3 levels and endothelial function in chronic haemodialysis (HD) patients. METHOD Blood samples were obtained from 116 chronic HD patients. We measured the endothelial function—represented by the vascular reactivity index (VRI)—via non-invasive digital thermal monitoring, and serum ANGPTL3 concentrations by using commercial enzyme-linked immunosorbent assay. RESULTS A total of 17 (14.7%), 50 (43.1%) and 49 (42.2%) patients had poor (VRI < 1.0), intermediate (1.0 ≤ VRI < 2.0) and good (VRI ≥ 2.0) vascular reactivity. As the VRI decreased, the serum alkaline phosphatase (ALP, P = .025) and ANGPTL3 (P < .001) levels significantly increased. Serum log-transformed ALP (log-ALP, r = –0.187, P = .045) and log-ANGPTL3 (r = –0.319, P < .001) were negatively associated with VRI values by univariate linear regression analysis. After applying multivariate stepwise linear regression analysis adjustment, the significantly negative association of log-ANGPTL3 (standardized β = –0.319, adjusted R2 change = 0.094; P < .001) with VRI values in chronic HD patients remained. CONCLUSION Our study results indicated that ANGPTL3 concentration was negatively associated with VRI values and modulated endothelial function in chronic HD patients.