Abstract
Diagnosis of malignant bile duct strictures based on the result of standard cytology of bile duct brushings is often challenging due to its low sensitivity. A small number of studies have shown that advanced cytological techniques such as fluorescence in situ hybridization (FISH) could lead to increased sensitivity of cytology. The limitations of advanced cytological techniques such as FISH are significant cost and limited availability. Fluid based approaches such as ThinPrep are cheap and readily available.
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