Mo1139 Coffee Consumption Genetic Polymorphisms in CYP1A2 and NAT2, and Colorectal Cancer Risk

Abstract

effect of race on survival time after adjusting for differences in stage, age and grade using Cox-proportional hazards regression. We used SPSS software (version 19.0) for the analysis. Results: We included 11,184 patients who were less than 50 years (9432 Caucasians and 1752 African-Americans) in our study. The mean (SD) age in years at diagnosis was similar in Caucasians 42(6) and African-Americans 42(6). Sigmoid colon was the commonest site affected in both groups (Caucasians 24% and African-Americans 20%). Differences in tumor characteristics at diagnosis is shown in Table 1. Surgery was performed in most of the patients in both groups (Caucasians 99% and African-Americans 100%). Mean survival was longer in Caucasian patients as compared to African-Americans (15 years vs. 12 years) P , 0.001 Log Rank (Mantel-Cox). Young Caucasians had better 5-year colon cancer-specific survival compared to African-Americans (62% vs. 52% respectively). After adjusting for differences in stage of disease at presentation, age and grade, African-Americans survive shorter time as compared to Caucasians (hazard ratio 95% CI 1.39 (1.28-1.51) (Figure 1). Conclusion: Young African-Americans had advanced stage of colorectal cancer at diagnosis. They had shorter survival time even after adjustment for differences of stage, grade and age. Table1: The characteristics of colorectal cancer in Caucasians and African-Americans