Mo1138 Erythrocyte Membrane Phospholipid Fatty Acid Concentrations and Colorectal Adenomas: A Case Control in Tennessee

Abstract

G A A b st ra ct s we reviewed patients > 18 years of age with rectal adenocarcinoma from 1991-2010. Continuous and categorical variables are reported using mean (SD), proportions, and percentages. Univariate analysis was done using T-test and Chi-square tests respectively. Multivariate Cox regression analysis was used to evaluate risk adjusted outcomes and to predict the hazard of dying. Kaplan Meier method was used to estimate the survival function. Results: We included 102,167 patients in our study. YPs with rectal carcinoma were more likely to be African American (11.9% vs 8.8%; p<0.001), Hispanic (13.3% vs 8.3%; p<0.001) and Asian (10.9% vs 8.3%; p<0.001) as compared to the older age group. YPs were more likely to present with distant metastasis (16.7% vs 13.4%; p<0.001) and had more poorly differentiated tumors (13.3 % vs 12.1%; p< 0.001). YPs also received more cancer directed surgery (84 % vs 80%; p<0.001) and post-operative radiation (52% vs 39.8; p<0.001) compared to their older counterpart. In contrast to previous studies the five year survival was better for younger patients (74.3% vs 70.7%; p<0.001{table 1}). After controlling for gender, race, marital status, grade, stage, cancer specific surgery and post-operative radiation, multivariate Cox regression analysis revealed that age is an independent predictor of death, and younger patients with rectal cancer had a lower risk of dying (HR 0.693; p<0.001) Conclusion: In previous studies younger patients with rectal cancer were found to have poorer or equivalent survival compared to older patients. In contrast, our study shows that young patients less than 50 years of age, have advanced stage rectal cancer at diagnosis but have better survival. Table 1: Five-year relative survival for rectal cancer patients