Mo1135 Trends in the Incidence of Esophageal Adenocarcinoma and Early Stage Esophageal Adenocarcinoma in the United States

Abstract

G A A b st ra ct s difference with 139 (65%) females and 74 (35%) males having IEM-A versus 5 (33%) females and 10 (66%) males with IEM-P (p = 0.035). The mean age of IEM-P patients (61.7 years) was significantly higher (p < 0.05) than that of IEM-A (55.7 years). There was no significant difference in the race: 153 (72%) whites, 56 (26%) blacks in IEM-A versus 11 (73%) whites and 4 (27%) blacks in IEM-P. 147/228 patients had an ambulatory reflux study done. 88 (61%) were abnormal. Of those 84 were IEM-A (60%) and 4 IEM-P (80%) (p = 0.36). Finally, abnormal bolus transit for both liquid and viscous was present in 10/ 11 (91%) of IEM-P versus 128/182 (70% of 182) of IEM-A. Failure to find p < 0.05 for reflux and bolus transit likely due to type II statistical error. Conclusions: These results support the hypothesis that there are 2 distinct clinical subtypes of IEM. Furthermore, they suggest that IEM-P with an older male predominance and with a trend to more severe reflux and more abnormal bolus transit is a more severe manifestation than IEM-A. IEM subtypes: IEM-A and IEM-P