Mo1016 Evaluation of Sarcopenia As a Predictor of Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic (TIPS) Shunt Placement

Abstract

A S L D A b st ra ct s subcutaneous fat (SF) were calculated in cm2 using the CT slice at the level of L 4 vertebra with Adobe Photoshop. We assessed differences in subcutaneous fat between compensated (Cc) and decompensated cirrhosis (Dc) and its determinants by multivariable linear regression. Results:We had complete data on 144 patients (44 compensated, 100 decompensated). Demographic characteristics were not significantly different between the two groups. The average MELD score was higher (18.4 in Dc vs. 14 in Cc; p<0.01). The average SMM was lower in Dc compared to Cc although this difference was not statistically significant (127 vs. 138 cm2, p=0.08). However, in males, SMM was significantly lower in Dc vs. Cc even after adjusting for race; age, serum albumin and MELD score (Coefficient of -16.1; 95% Confidence Interval -32.2 to -0.1; p=0.04). [Table 1]. Conversely in females, sf was lower in Dc vs. Cc when adjusted for above confounders with a trend towards significance (Coefficient of -127.3; 95% Confidence Interval -258.9 to 3.3; p=0.057). There was no difference in SF between Dc and Cc males and SMM between Dc and Cc females respectively. Conclusions: Skeletal muscle is reduced to a greater extent in males and subcutaneous fat is reduced to a greater extent in females as cirrhosis becomes decompensated, as seen in other chronic diseases These changes in decompensated cirrhosis may depend on pre morbid body composition with females losing more fat due to higher baseline body fat percentage and males losing more lean muscle mass for the same reasons. Further investigation into these mechanisms is warranted. Univariable and multivariable linear regression of SMM and SF in males and females