Abstract
Ménétrier’s disease (MD) is a rare type of hypertrophic gastropathy involving the body of the stomach, which is characterized by thickening of the mucous membrane in the form of giant rugal folds, hypochlorhydria and protein loss. The potential for malignant transformation of this lesion remains a controversial topic. Therefore, in the present study, a case of a 51-year-old male exhibiting MD with coexisting advanced gastric cancer is described; a review of the literature is also presented. The present case emphasized that MD requires particular attention and should be regarded as a premalignant condition due to the previously documented cases of its coexistence with gastric cancer, in addition to the lack of knowledge regarding its pathogenesis and effective therapeutic management.
Highlights
Ménétrier's disease (MD) with infections (Helicobacter pylori, CMV, herpes simplex, human immunodeficiency virus [HIV], Mycoplasma pneumoniae) [4,6,7,8,9] as well as non‐specific inflammatory diseases [10]
A patient with MD and advanced gastric cancer is described and a review of the literature is presented, which indicates that MD should be recognized as a premalignant condition
Since MD is rare and difficult to discriminate from other hypertrophic gastropathies, Rich et al [2] proposed an algorithm for its recognition
Summary
MD with infections (Helicobacter pylori, CMV, herpes simplex, human immunodeficiency virus [HIV], Mycoplasma pneumoniae) [4,6,7,8,9] as well as non‐specific inflammatory diseases (including ulcerative colitis) [10]. A large neoplastic infiltration was identified, ~5 cm in diameter, with a 35‐mm crater ulceration at PRYCZYNICZ et al: A CASE OF MÉNÉTRIER'S DISEASE AND ADVANCED GASTRIC CANCER. The postoperative formalin‐fixed sample showed a tumour situated on the anterior wall of the stomach, partly on the lesser curvature, which was 10 cm at the greatest diameter. An additional lesion was identified on the posterior wall of the stomach, located 3 cm away from the other tumour. The microscopic examination of the first lesion demonstrated tubular and papillary adenocarcinoma and was classified histologically using the 7th edition of the Union for International Cancer Control classification [11] as extending to the serosal mucosa (pT3) with a moderately differentiated malignancy (G2) [12]. The immunohistochemical analysis for human epidermal growth factor receptor 2 was negative, and metastases to 21/78 lymph nodes and tumour infiltration of the pancreatic tail were observed (Fig. 3).
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