Abstract
A novel manganese(II) complex of a di-2-pyridyl ketone N(4)-phenyl thiosemicarbazone (HL) was synthesized and characterized. Single crystal X-ray diffraction studies revealed that the asymmetric unit of the triclinic unit cell contained two independent Mn(L)2 molecules together with two water molecules of crystallization and a DMF molecule. DNA binding studies of the ligand and its complex were conducted using absorption titrations, fluorescent intercalator displacement assays and viscosity measurements. Both the ligand and the complex were found to show good DNA binding abilities and actively displaced the standard intercalator ethidium bromide. In addition to the DNA binding studies, antimicrobial activities of the compounds were also determined and the complex exhibited higher antibacterial activity compared to the ligand HL. Another interesting property exhibited by the manganese complex was its colorimetric sensing, making it an excellent probe for naked-eye detection of Fe2+ and Ru3+ ions, with a visible color change from yellow to colorless. The recognition ability of the ions by the probe was quantitatively analyzed using a titration [ion]/[complex] ratio of 0–2.
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