Mnemonic discrimination is associated with individual differences in anxiety vulnerability

Abstract

Increased generalization between fear-inducing stimuli (e.g., looking over the edge of a tall building) and perceptually-similar neutral stimuli (e.g., an aerial photograph) is observed in all subtypes of anxiety disorders, leading to avoidance behaviors that feed forward from the feared stimulus to other, seemingly unrelated stimuli. However, recent research suggests a much more nuanced relationship between generalization, discrimination, and behavior. This study seeks to extend current understanding by using a mnemonic discrimination task to explore the relationship between risk for anxiety and differences in mnemonic discrimination abilities. Participants self-reported trait anxiety and behavioral inhibition (a temperamental construct linked to risk for anxiety), and also completed a memory task. After incidental encoding of color photographs of neutral everyday objects, participants performed a surprise recognition task, where they categorized each test image as “old” (identical to a previously viewed image), “similar” (new but perceptually-similar to a studied image, with half the images being highly similar and the other half being less similar to the studied images), or “new” (new and perceptually-dissimilar to studied images). We found that those with high behavioral inhibition are more successful at discriminating between previously seen “old” items from highly similar items. In contrast, those with high trait anxiousness are less successful at the same kind of discrimination. Interestingly, these relationships were not apparent in low similarity items. Our data suggest that behavioral inhibition and trait anxiety may be associated with unique aspects of individual differences in mnemonic discrimination abilities.