Mn導入骨類似組成リン酸カルシウムセメントの創製

Abstract

Amorphous calcium phosphate (ACP) is known as a precursor of hydroxyapatite (HAp) which is an inorganic main component of bone. The ACP gradually crystallizes to low crystalline apatite near human body temperature. If we introduce an active ingredient at the time of synthesis of ACP and we can introduce an ingredient effective for bone repair or an ingredient having functionality into the crystal structure of HAp, an active ingredient-releasing material responsive to bone metabolism would obtaine, and the protein might produce. Mn is an essential trace element in the living body and is present in the body as an active metal such as Mn-SOD (Mn-superoxmutase) having an antioxidant activity and enhancing the activity of proteoglycan synthetase during bone formation. In this research, we try to introduce Mn into ACP, prepare cement using the obtained powder. In the synthetic powder, Mn was introduced at the same rate as the preparation. The obtained cement had crystallized and low-crytalline bone-like apatite composition. The porosity changed with the amount of Mn added. The cements exhibited protein adsorption properties regardress of the addition of Mn. It is expected that proteins involved in bone metabolism adsorb to the cement.