Abstract
Reported is the synthesis of highly substituted pyrroles through a Mn(III)-catalyzed radical-based cycloaddition. The proposed mechanism proceeds by Mn(III)-catalyzed decarboxylation to generate an α-carbonyl radical, which then undergoes reaction with the vinyl azide, forming a new carbon-carbon bond and ejecting N2 to generate an iminyl radical. This iminyl radical then undergoes a Mn(II)-driven condensation with the remaining carbonyl to generate the desired products and regenerate the Mn(III) catalyst. Although this mechanism is presented without evidence (e.g. no indication of byproducts), each of the steps is entirely reasonable and it represents a good working hypothesis for the further utility of vinyl azides in this kind of reaction.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
