Abstract
Reaction of acetylsalicylic acid (aspirin) (H2L) with Mn(II), Co(II), Ni(II) and Zn acetates allow to obtain salicylates of related metals. The solid-state structures of prepared complexes were determined by single crystal X-ray crystallography and spectroscopic techniques. Zinc, nickel and cobalt(II) complexes are mononuclear and their crystal structures composed of neutral discrete molecules [Zn(sal)2(H2O)2], [Ni(sal)2(H2O)4] and [Co(sal)2(H2O)4] while manganese derivative has 2D polymeric structure. The cardiorespiratory and skin microcirculation activity of these metal complexes was evaluated. Particularly, the promising therapeutic activities displayed by 1–4 complexes make them potential candidates for the development of a promising drugs.
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