Abstract
Aim: To compare liver enhancement and lesion-liver contrast on T1-weighted (T1W) gradient recalled echo (GRE), spin-echo (SE) and fat-suppressed SE (FS-SE) pulse sequences at Manganese-DPDP (Mn-DPDP) enhanced magnetic resonance (MR) imaging of the liver. Patients and Methods: Twenty-one patients with known liver lesions were administered 5 μmol/kg of Mn-DPDP. TIW GRE (78/2.3/80°), SE and F-SE (300/12) images were obtained before and 15min after Mn-DPDP. Signal/noise ratio (SNR) and lesion-liver contrast/noise ratio (CNR) were calculated for each pulse sequence. Results: Liver SNR ( n = 21) and lesion-liver CNR ( n = 10) increased significantly after Mn-DPDP on all three pulse sequences ( P < 0.0001). Liver SNR was highest on the FS-SE and GRE pulse sequences (FS-SE = 43.8, GRE = 38.4, SE = 29.2). Lesion-liver CNR was highest on the FS-SE pulse sequence (FS-SE = −29.3, SE = −23.2, GRE = −19.8), which was significantly higher than the GRE pulse sequence ( P < 0.05). Conclusion: The T1-weighted fat-suppressed SE (FS-SE) pulse sequence provides highest liver enhancement and lesion-liver contrast and is recommended for Mn-DPDP enhanced MR imaging.
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