Abstract
This work presents a novel approach to producing manganese (Mn)-doped quantum dots(Mnd-QDs) emitting in the near-infrared (NIR). Surface functionalization of Mnd-QDswith lysine makes them stably disperse in aqueous media and able to conjugate withtargeting molecules. The nanoparticles were structurally and compositionally characterizedand maintained a high photoluminescence quantum yield and displayed paramagnetism inwater. The receptor-mediated delivery of bioconjugated Mnd-QDs into pancreatic cancercells was demonstrated using the confocal microscopy technique. Cytotoxicity of Mnd-QDson live cells has been evaluated. The NIR-emitting characteristic of the QDshas been exploited to acquire whole animal body imaging with high contrastsignals. In addition, histological and blood analysis of mice have revealed that nolong-term toxic effects arise from MnD-QDs. These studies suggest multimodalMnd-QDs have the potentials as probes for early pancreatic cancer imaging anddetection.
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