Abstract
This study investigated the pivotal role of fibronectin cleaved by MMP-9 in enhancing the attachment of monocytes to tumor cells. To determine whether MMP-9 induces changes in the extracellular matrix fibronectin of tumor cells and increases monocyte adhesion, human glioblastoma U87MG cells expressing MMP-9 were established by transfection. The human monocyte U937 cells adhered significantly to U87MG cells expressing MMP-9, however, they did not adhere to U87MG cells that did not express MMP-9. To directly demonstrate the role of MMP-9-cleaved fibronectin in increasing monocyte U937 cell adhesion, the attachment of monocyte U937 cells to fibronectin treated with MMP-9 was confirmed. These findings suggest that MMP-9 alters the extracellular matrix, specifically fibronectin, and plays a crucial role in mediating the adhesion between immune and tumor cells.
Published Version
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