Abstract
RATIONALE: Collagen is an extracellular matrix protein involved in airway fibrosis and has been implicated in the pathogenesis of airway remodeling in asthma. We have previously demonstrated that IL-13 increased collagen type 1 alpha 2 (COL1A2) mRNA and protein expression in human airway fibroblasts from asthmatic patients compared to normal controls. Our data has shown that this IL-13 induced expression may be attenuated using a non-specific Matrix Metalloproteinase (MMP) inhibitor suggesting that MMPs mediate IL-13 induced collagen expression.
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