Abstract
MuLLERIAN inhibiting substance is a glycoprotein hormone produced by fetal Sertoli cells that causes regression of the mullerian ducts in males during sexual differentiation.1 2 3 Serum concentrations of this hormone remain high in boys for several years, but then decline by puberty.4 During normal female development, in the absence of mullerian inhibiting substance, the mullerian ducts give rise to the fallopian tubes, uterus, and upper third of the vagina.1 Postnatally, granulosa cells also secrete this hormone,5 resulting in serum concentrations in pubertal girls and women that are similar to those in men. A potential role for mullerian inhibiting substance in the . . .
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