Abstract
Gene therapy for retinal diseases has gained increasing attention in recent years (see review, Bennett and Maguire, 2000). Among various gene delivery systems, viral vectors such as adenovirus (Ad), adeno-associated virus (AAV) and lentivirus appear to be the most efficient vehicles for gene transfer. In comparison to the Ad and lentivirus, AAV offers several advantages, including nonpathogenicity, minimal immuogenicity, and stable transgene expression in a wide host range (Flotte and Carter, 1995; Bennett et al., 1999; Anand et al., 2000
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