Abstract
MLL is required for miRNA-mediated translational repression
Highlights
1234567890():,; 1234567890():,; 1234567890():,; 1234567890():,; Dear Editor, The mixed-lineage leukemia (MLL) protein was originally identified through its association with acute lymphoid and myeloid leukemias[1]
MLL dominantly localized to the nucleus, a significant portion of MLL was present in discrete cytoplasmic foci, colocalizing with P-body marker proteins such as DCP1A, DDX6, EDC3, and EDC4
Since our results showed that YB-1 as well as stress granules (SGs) marker eIF3 was binding partner of MLL (Fig. 1a and Supplementary Fig. S1a), we investigated whether MLL was a component of SGs
Summary
1234567890():,; 1234567890():,; 1234567890():,; 1234567890():,; Dear Editor, The mixed-lineage leukemia (MLL) protein was originally identified through its association with acute lymphoid and myeloid leukemias[1]. To verify the connections between MLL and P-bodies, we examined several P-body marker proteins including DCP1A, DDX6, EDC3, and EDC4 in endogenous MLL immunoprecipitates, and confirmed a physical interaction between MLL and these P-body components (Fig. 1a and Supplementary Fig. S1a).
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