MK-7 enhances expression of genes related to bone, enamel and dentin, and reduces the expression of genes related to apoptosis in developing murine molars

Abstract

Conclusions A clear effect on gene expression in the developing tooth germ was apparent after 24 h at all dosages. The results indicate increased transcription of genes involved in development of bone, increased biosynthesis of important carbohydrates and of enamel/dentin, and reduced expression of apoptosis related proteins. Further investigations are, however, required to elucidate these findings. Such experiments will likely entail the establishment of a clear dose-response relationship and long term use of MK-7. Also, effects of oral administration should be studied. Background Menaquinone-7 (MK-7) it’s a fat-soluble vitamin and a vitamin K2 homologe needed for post-translational modification of certain proteins required for blood coagulation, and in metabolic pathways in bone and other tissues. Recent studies found an association between long-term anticoagulant treatment (OAC) and reduced bone quality due to reduction of active osteocalcin. OAC is often linked to an undesired soft-tissue calcification in both children and adults. OAC often leads to increased incidence of fractures, reduced bone mineral density/bone mineral content, osteopenia and increased serum levels of undercarboxylated vitamin Kdependent proteins, known as Gla-proteins. Litle is known about the effects of vitamin K2 during tooth development.