Mixture Interpretation (Interpretation of Mixed DNA Profiles With STRs)

Abstract

Forensic DNA profiling methodology has improved in sensitivity since the introduction of short tandem repeat (STR) analysis in the 1990s. Today, commonly used DNA profiling technology target over 20 STR regions and is able to generate DNA profile data from sub-single-cell DNA amounts. Mixed DNA profiles are often encountered in casework. Methods of profile interpretation have accordingly changed to address the enhanced sensitivity of the methods. In this article we describe the methods of classic and modern profile interpretation and the important characteristics considered during profile interpretation.