Mixture for Controlling Insecticide-Resistant Malaria Vectors

Cédric Pennetier,Fabrice Chandre,Roch K Dabiré,Vincent Corbel,Carlo Costantini,Séverine Licciardi,Jean-Marc Hougard,Bruno Lapied

doi:10.3201/eid1411.071575

Cédric Pennetier, Fabrice Chandre + Show 6 more

Open Access

https://doi.org/10.3201/eid1411.071575

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Abstract

The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations. To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso. During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes. The mixture seemed to not kill more susceptible genotypes for the kdr or Ace1R alleles. Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified.

Highlights

To cite this version: Cédric Pennetier, Carlo Costantini, Vincent Corbel, Séverine Licciardi, Roch Dabiré, et al
The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations
To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticideresistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso

Summary

Introduction

To cite this version: Cédric Pennetier, Carlo Costantini, Vincent Corbel, Séverine Licciardi, Roch Dabiré, et al. Mixture for Controlling Insecticide-Resistant Malaria Vectors. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations. During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes. Mixing repellents and organophosphates on bed nets could be used to control insecticideresistant malaria vectors if residual activity of the mixture is extended and safety is verified

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Conclusion