Abstract
Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions.
Highlights
Invasive candidiasis remains one of the most prevalent systemic mycoses [1,2,3]
6895 (2%) tested positive for yeast cultures, and mixed yeast (MY) infections accounted for 150 cases (2.2%)
266,579 sterile specimens were tested: 2840 (1.1%) tested positive for yeast cultures and MY infections accounted for 118 cases (4.2%)
Summary
Invasive candidiasis remains one of the most prevalent systemic mycoses [1,2,3]. The mortality associated with this infection is substantial, and it has been estimated to be between 10% to 47% [1,4]. Candida albicans is the most common species isolated, but surveillance studies have documented an increasing rate of non-albicans and frequently more resistant species, such as C. glabrata [3,5,6]. Several studies have reported mixed yeast (MY) infections [7,8,9,10,11]. The detection of mixed fungemia increased from no cases to 2.8%
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