Abstract
Multi-modal chromatography emerged as a powerful tool for the separation of proteins in the production of biopharmaceuticals. In order to maximally benefit from this technology it is necessary to set up an optimal process control strategy. To this end, we present a mechanistic model with a recent kinetic adsorption isotherm that takes process controls such as pH and buffer salt concentration into account. Maximizing the yield of a target component subject to purity requirements leads to a mixed-integer nonlinear optimal control problem constrained by a partial differential equation. Computational experiments indicate that a good separation in a two-component system can be achieved.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
