Abstract
Components with equal effective mobilities migrate unseparated in steady state mixed zones in isotachophoresis. In case the separation selectivity cannot be enhanced, quantitative analysis is possible only by the use of selective detection. In this paper, mass spectrometry is applied as selective off-line detection method for the determination of the mole fractions of the two constituents in the mixed zone. The combination of the information obtained by mass spectrometry, the mole fractions, and by isotachophoresis, the total amount of both compounds, enables the determination of the absolute amounts of each component. In this approach, the quantitative analysis of a sample mixture, consisting partially of components with equal effective mobilities, is carried out. The performance of the method is demonstrated by a practical example: the analysis of the hydrogenation products of aromatic quaternary ammonium ions as parent compounds.
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