Mixed Micellization and Spectroscopic Studies of Anti-Allergic Drug and Non-Ionic Surfactant in the Presence of Ionic Liquid.

Naved Azum,Malik Abdul Rub,Abdullah M Asiri

doi:10.3390/polym13162756

Abstract

In drug delivery, surfactants are used to reduce side effects and to increase drug efficiency. The present work aimed to study the interaction of diphenhydramine hydrochloride (anti-allergic drug) with TX–45 (non-ionic surfactant) in the absence and presence of ionic liquid (1-hexyl-3-methylimidazolium chloride). The physicochemical parameters were estimated by the surface tension measurement. Various theoretical models (Clint, Rubingh, Motomura, and Maeda) were applied to determine the attractive behavior between drug and surfactant mixtures at the surface and in bulk. The drug and surfactant mixtures exhibit synergistic behavior in the absence and presence of ionic liquid. Several energetic parameters were also estimated with the assistance of regular solution approximation and pseudo phase separation model that indicate micelle formation and adsorption of surfactant at the surface is thermodynamically advantageous. The morphology of pure and mixture of amphiphiles has been estimated by the Tanford and Israelachvili theories. UV-visible spectroscopy was used to quantify the attractive behavior of the drug with surfactant with the help of a binding constant (K).

Highlights

IntroductionLow bioavailability due to the poor solubilization of hydrophobic drugs is the main problem associated with drug therapy
We investigated the mixed system of numerous amphiphilic drugs with different surfactants or amphiphiles using different techniques [24,25,26,27,28,29,30,31,32,33]
The tension (Figure after the2).addition an amphiphile is due to prominent techniques used to understand theamphiphiles

Summary

Introduction

Low bioavailability due to the poor solubilization of hydrophobic drugs is the main problem associated with drug therapy. Due to this poor availability, a large quantity of drugs is required to complete the therapy. Surfactants can act as a delivery agent that solubilizes the drug and raises the bioavailability of drug molecules. Surfactants or surface-active agents are amphipathic molecules having polar and non-polar parts in the same body. Due to this dual character, they have one of the exiting features of selfaggregation or micelle formation. Micelles are labile entities formed by the noncovalent association of individual surfactant monomers

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Conclusion