Mixed-ligand complex [Cu4(bpy)4(PO4)2(CO3)(H2O)2]: synthesis, crystal structure and biological properties

Abstract

The interaction in the system {Сu(OAc)2·H2O–phytic acid–2,2`-bipyridine (bpy)} in an aqueous-methanol solution led to the formation of a molecular mixed-ligand tetranuclear complex [(Cu4(bpy)4(PO4)2(CO3 )(H2O)2]13H2O (I), the structure of which was established based on the results of an X-ray diffraction experiment (CCDC 2262998). According to X-ray diffraction data, the molecule contains four nonequivalent Cu2+ cations, which coordinate two phosphate anions (PO43-, remaining as a result transformation of the phytate cycle), four neutral bpy, two water molecules and one carbonate anion fragment (CO32-). The presence of a large number of solvate water molecules in the outer coordination sphere created a hydrogen-bonded framework involved in the stabilization of the crystal packing. Study of antimycobacterial activity of I in against the non-pathogenic strain Mycolicibacterium smegmatis showed its high bioeffectiveness.