Mixed invasion of H. pylory and Protozoa as a pathogenetic factor of diseases of the upper digestive tract

Abstract

Modern research indicates a possible synergistic effect of bacterial-protozoal infestations in the pathology of the upper gastrointestinal tract, among which special attention is paid to the problem of giardiasis. Other parasitic agents, in particular Blastocystis spp, are also gaining some significance. The aim is to study the prevalence of H. pylori and protozoal infestations in chronic gastroduodenal diseases and the influence on the indicators of enzymatic digestion. Materials and methods. We examined 244 patients (130 adults and 114 children) with clinical manifestations with abdominal pain and dyspeptic syndromes. All patients were examined by immunochromatographic test for the qualitative detection of H. pylori in the feces, coprological and protozoological methods. Results. In the group of patients with chronic gastroduodenal diseases, the H. pylori antigen in the feces was detected in 116 (47.5%) patients. During protozoooscopic examination of feces, the detection rate of Lamblia intestinalis was 22.9%, in Blastocystis spp. - 13.1%, Entamoeba coli 10.2%, Entamoeba spp. 9.4%. Protozoan invasion was detected in the groups of H. pylori + and H. pylori - patients: infection of Lamblia intestinalis was diagnosed in 27.6% and 18.8% of cases respectively (p<0.05), in Blastocystis spp. - in 16.4% and 10.2% cases (p<0.05). There were no significant differences in the frequency of detection of non-pathogenic amoebas in these groups of patients. Mixed infection with H. pylori and pathogenic protozoa, along with increased manifestations of gastrogenic, ileocecal, enteral and acholian syndrome, signs of pancreatogenic and distal-colitic syndromes were detected. Monoinfection Lamblia intestinalis, signs of enteral, ileocecal, and acholia with signs of ileocecal syndromes were detected, and when monoinfection Blastocystis spp. signs of enteral and ileocecal syndromes were revealed. Conclusions. It is shown that intestinal protozoan and bacterial-protozoan mixed infection (H. pylori + L. intestinalis; H. pylori + Blastocystis spp.) can have a negative effect on enzyme digestion and are important etiopathogenetic factors of diseases of the upper gastrointestinal tract.