Mixed IgG, IgM and IgA Cryoglobulin Response in Human Typhoid Patients

Abstract

Cryoglobulin response appeared within one to four days at 4°C and redissolved at 37 and 45°C within 1/2 to 2.1/2 hrs . The texture of the cryoglobulin was gelatinous 49:60( 81.7 % ) and flocculent 8: 60 ( 13.3 % ) . The mean of cryocrit percent among typhoid patients was 6.1 % while among control was 0.2 Cryoglobulin response was associated with RF in 28:57 ( 49.12 % ) among typhoid patients sera and nil among controls . The immunofixation studies using radial immunodiffusion in gel have shown that type of cryoglobulin response was of mixed type IgG-IgM-IgA . The RF associated cryoglobulinemia have shown higher IgG concentration than non RF associated cryoglobulin . The Ig classes have shown individual variations .S.typhi O agglutinins were 46:57 ( 80.7 % ) in typhoid . Thus , type IIIsecondary mixed IgG-IgM-IgA cryoglobulinemia associated with typhoid patients sera with S.typhi O specific cold agglutinins as well .