Mixed (combined) phenotype of the late stage of age-related macular degeneration

N V Neroeva,V V Neroev,A G Karmokova,O A Losanova,M V Ryabina

doi:10.21516/2072-0076-2021-14-2-69-75

Abstract

With multimodal visualization of the chorioretinal complex structures using modern research methods, it was possible to isolatea mixed, or combined, phenotype of the late stage of age-related macular degeneration (AMD). Early detection of this AMD form is of vital importance not only for accurate diagnosis, but for choosing optimal management tactics for patients. The paper presents two clinical cases with different variants of the development of the mixed phenotype of the late AMD stage. In one case, the long-lasting “geographic atrophy” (GA) was complicated by the development of choroidal neovascularization, while in the other case GA appeared during the treatment of wetAMD.

Highlights

With multimodal visualization of the chorioretinal complex structures using modern research methods, it was possible to isolate a mixed, or combined, phenotype of the late stage of age-related macular degeneration (AMD). Detection of this AMD form is of vital importance for accurate diagnosis, but for choosing optimal management tactics for patients
The long-lasting “geographic atrophy” (GA) was complicated by the development of choroidal neovascularization, while in the other case GA appeared during the treatment of wet AMD
Images of the posterior pole of the right eye fundus in the Multicolor mode (A), infrared light, vertical and horizontal sections of OCT of the OD (Б, В): the new appearing GA focuses were added to the existing changes, clearly distinguishable in the AF study (Г)

Summary

Introduction

With multimodal visualization of the chorioretinal complex structures using modern research methods, it was possible to isolate a mixed, or combined, phenotype of the late stage of age-related macular degeneration (AMD). ГА и ХНВ принято считать двумя вариантами поздней ВМД (IV стадии по классификации AREDS). ЦЕЛЬЮ работы является описание случаев сочетания ГА и ХНВ на одном глазу, характеризующих комбинированный фенотип поздней стадии ВМД.

Results

Conclusion