Abstract
Mixed adenoneuroendocrine carcinoma is a rare neoplasm with both epithelial and neuroendocrine components. To date, only a few cases of this neoplasm have been reported in the literature among which gastric mixed adenoneuroendocrine carcinoma is very rare. We are reporting a case of gastric mixed adenoneuroendocrine carcinoma with squamous cell differentiation. Histopathological features, biological behaviour and the treatment of this rare tumour type have been discussed briefly.
Highlights
Mixed adenoneuroendocrine carcinoma (MANEC) is a rare neoplasm defined by the World Health Organization(WHO) in 2010 as neoplasms consist of dual adenocarcinomatous and neuroendocrine components with a variable grade of differentiation
High-grade malignant MANEC are defined by an adenomatous or adenocarcinomatous component with a neuroendocrine carcinoma (NEC) and the prognosis of these tumours depends on the aggressive NEC component
Intermediate-grade MANEC are formed by an adenocarcinoma component and by a neuroendocrine tumour (NET) in which the exocrine part of the tumour is more aggressive than the neuroendocrine component
Summary
Mixed adenoneuroendocrine carcinoma is a rare neoplasm with both epithelial and neuroendocrine components. Only a few cases of this neoplasm have been reported in the literature among which gastric mixed adenoneuroendocrine carcinoma is very rare. We are reporting a case of gastric mixed adenoneuroendocrine carcinoma with squamous cell differentiation. Histopathological features, biological behaviour and the treatment of this rare tumour type have been discussed briefly.
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