Abstract
Mitral valve prolapse is usually a primary, dominantly inherited condition with more consistent gene expression in women than in men or children. Diagnosis is by midsystolic click/late systolic murmur; echocardiography confirms and documents severity. True mitral valve prolapse syndrome is characterized by low body weight and blood pressure, minor skeletal abnormalities, orthostatic hypotension, palpitations, and mitral regurgitation of variable degree. Complications are progressive mitral regurgitation, infective endocarditis, and possible risk of arrhythmic sudden death and orthostatic syncope. Risk factors for complications indude older age, male gender, mitral regurgitant murmur, and possibly greater weight and higher blood pressure. Presence and severity of mitral regurgitation govern frequency and intensiveness of follow-up.
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