Abstract
Mitotic transformation of TRAMM/TrappC12.
Highlights
Transport protein particle (TRAPP) has been demonstrated to contribute to endoplasmic reticulum (ER)-to–Golgi, intra-Golgi and late Golgi anterograde membrane transport as well as autophagy in both yeast and higher eukaryotes
We demonstrated that TrappC12, is a novel mitotic regulator with an important role in kinetochore assembly and stability that controls the recruitment of CENP-E to the kinetochores
Our study began with the observation that TRAMM depletion, but not of any other TRAPP subunit, resulted in a dramatic increase in the mitotic index
Summary
Transport protein particle (TRAPP) has been demonstrated to contribute to endoplasmic reticulum (ER)-to–Golgi, intra-Golgi and late Golgi anterograde membrane transport as well as autophagy in both yeast and higher eukaryotes. The protein interacts with ERK2, modulates the nuclear localization of phospho-ERK2 and regulates proliferation and apoptosis in colorectal cancer cells. TrappC4 depletion induces cell cycle arrest in the G0/G1 phase and downregulates the expression of cyclin B1.
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