Abstract

This paper concerns the mechanism of mitosis. I briefly review the history of mitosis research, emphasizing the role of microscopic observation. The polymerization and depolymerization of microtubules play central roles in both the assembly of the spindle, and in the way it moves chromosomes. I describe recent advances in understanding the dynamic behavior of individual microtubules, and of microtubules attached to kinetochores. The kinetochore is able to hold on to microtubule ends while allowing them to grow and shrink, reactions that can be studied both in living cells and in the test tube. Experiments in which microtubules in living cells are marked and then followed allow us to relate these individual dynamic processes to the overall mechanism of chromosome movement. I end the review by speculating about biochemical mechanisms for producing force on chromosomes in anaphase, and for balancing chromosomes in the center of the metaphase spindle.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.