Abstract
Mitochondria are key organelles inside the cell that house a wide range of molecular pathways involved in energy metabolism, ions homeostasis, and cell death. Several computational solutions have been publicized to characterize the different mitochondrial aspects and thus support basic and clinical research. Most of them consist of web inventories of the mitochondrial proteome and interactome or collection of human mitochondrial DNA variations. However, no published databases that provide the detailed characterization of multiple mitochondrial pathways and their association with different processes are available to date. Here, we present MitopatHs (https://web.math.unipd.it/mitopaths/), a new mitochondrial-focused resource that allows to navigate among the biochemical signalling pathways (PatHs) of human (H) mitochondria (Mito). MitopatHs is constructed to dissect virtually all types of pathways in two complementary ways: a logical view, where the sequence of biochemical reactions is presented as logical deductions, and an intuitive graphical visualisation, which enables the examination and the analysis of each step of the pathway. MitopatHs is a manually curated, open access and collaborative web tool, whose primary goal is not to produce publication-ready figures but to enable the comprehension of a complicated molecular route in an easy and fast way.
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