Mitomycin‐C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high‐risk locations

Abstract

To report on the use of Mitomycin-C as adjuvant therapy to excision and cryotherapy in patients with sebaceous gland carcinoma (SGC) in high-risk locations. Retrospective, consecutive, case series. Three patients with SGC of the upper palpebral conjunctiva or caruncle, but without clinical pagetoid spread. Following excision and double freeze-thaw cryotherapy, patients with histology demonstrating SGC of the ocular surface were treated with topical Mitomycin-C (0.04%). Follow-up was conducted over an average of 30 months (range: 24-37 months). Postoperative evidence of local recurrence, lymph node or distant organ metastasis. No patients had evidence of local recurrence or systemic disease. Wide surgical excision with cryotherapy is the basis of treatment of SGC without pagetoid spread. The use of Mitomycin-C as adjuvant therapy remains controversial, although there is some rationale for its use in high-risk situations.