Mitomycin-C/5-FU and radiation therapy for locally advanced uterine cervical cancer

Abstract

To assess the feasibility and effectiveness of combined therapy on locally advanced cervical cancer, we entered 38 patients into a study. The patients were treated with mitomycin-C (10 mg/m 2) on Days 1 and 30 and 5-FU (1000 mg/m 2) on Days 1 to 4 and Days 30 to 33. In 5 weeks 4500–5000 cGy was given concurrently, followed by radioactive implants. Twenty-six patients had an early-stage disease (IB–IIB) and twelve had a late-stage disease (IIIB–IVA). Eighty-seven percent ( 33 38 ) of the patients had a tumor measuring 5 cm or more. The other 5 patients with a tumor size under 5 cm had biopsy-proven positive pelvic nodes; 2 of these 5 patients had a pretherapy hysterectomy. Tumor response, complete (CR) vs partial (PR), was assessed in 36 patients 3 months after completion of therapy. A CR was noted in 80% ( 29 36 ) of the patients. The PR status conferred a detrimental effect on the pelvic disease control (PDC), disease-free survival (DFS), and survival (S) while late stage correlated with the development of distant metastases (DM) and a poor DFS. PDC was obtained in 93% ( 27 29 ) of the patients who had a CR, as compared to only 43% ( 3 7 ) of those with a PR ( P = 0.0228). The DFS and S rates were 59 and 77% for patients with a CR and 21 and 19% for those with a PR; respective P values were 0.0340 and 0.0002. Eleven percent ( 3 26 ) of the patients with an early stage developed DM, as compared to 50% ( 6 12 ) of those with late stage, ( P = 0.0016). The DFS rates were 80 and 37% for patients with an early and late stage, respectively ( P =0.0141). Four patients developed transient neutropenia and one had transient thrombocytopenia. The second dose of mitomycinC was omitted in 4 patients due to persistent neutropenia in 3 and to transfusion-related hepatitis in 1. Two percent ( 5 21 ) of the patients who had a staging laparotomy developed wound dehiscence. Three patients developed non-cancer-related small bowel obstruction requiring surgery. We concluded that this combined regimen was well tolerated. Although it was effective in controlling the cancer in the pelvis, this regimen failed to control DM in late-Stage patients.