Abstract
I. A. Al-Meshal. Mitodepressive effect of (−)-cathinone from Catha edulis (khat), on the meristematic region of Allium cepa root tips. Toxicon 25, 451 – 454, 1987.(−)-Cathinone, a psychostimulant alkaloid from khat, showed a significant mitodepressive effect on the dividing cells of Allium cepa root tips. This effect was dose-dependent and irreversible. Exposure of root cell to cathinone for 48 hr produced significant condensation and clumping of chromosomes, sticky metaphases and anaphase bridges. Our study suggests that the teratogenic and mutagenic effects of khat extracts as reported by earlier workers might be partially or totally due to their (−)-cathinone content.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
