Abstract
Mammalian mtDNA is packaged in DNA-protein complexes denoted mito-chondrial nucleoids. A combination of super-resolution STED microscopy and molecular biology was used to study mitochondrial nucleoids in mammalian cells. Mitochondrial nucleoids have a defined, uniform mean size of about 100 nanometers. Interestingly, the nucleoid frequently contains only a single copy of mtDNA. These fundamental insights into the organization of mtDNA have broad implications for understanding mitochondrial dysfunction in disease and ageing.
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Schedule a callMore From: Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)
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