Abstract
Tethers that link mitochondria to other organelles are critical for lipid and calcium transport as well as mitochondrial genome replication and fission of the organelle. Here, we review recent advances in the characterization of interorganellar mitochondrial tethers in the budding yeast, Saccharomyces cerevisiae. We specifically focus on evidence for a role for mitochondrial tethers that anchor mitochondria to specific regions within yeast cells. These tethering events contribute to two processes that are critical for normal replicative lifespan: inheritance of fitter mitochondria by daughter cells, and retention of a small pool of higher-functioning mitochondria in mother cells. Since asymmetric inheritance of mitochondria also occurs in human mammary stem-like cells, it is possible that mechanisms underlying mitochondrial segregation in yeast also operate in other cell types.
Highlights
Mitochondrial Tethers and Their Impact on Lifespan in Budding YeastReviewed by: Johannes Herrmann, Kaiserslautern University of Technology, Germany
Mitochondria have emerged as central regulators of lifespan through multiple mechanisms
Deletion of MFB1 results in a significant decrease in replicative lifespan. These findings indicate that anchorage of a small population of higherfunctioning mitochondria in the mother cell tip is mediated by Mfb1 and that this process affects cellular fitness and lifespan
Summary
Reviewed by: Johannes Herrmann, Kaiserslautern University of Technology, Germany. Specialty section: This article was submitted to Mitochondrial Research, a section of the journal
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