Abstract
Hypochlorous acid (HClO) as a reactive oxygen species (ROS) played an important role in many pathological and physiological processes. HClO could kill invading pathogens and bacteria in the immune system. But excessive concentrations of HClO may cause many diseases. Near-infrared fluorescent probes have strong tissue penetrating ability, low autofluorescence interference, and broad application prospects in the field of fluorescence imaging research. In this work, we synthesized a new near-infrared (670 nm) “dual-mode” fluorescent dye NSSN based on the benzothiazole framework for the visual detection of HClO. The NSSN had a large Stokes shift (220 nm), good selectivity, ratiometric near-infrared and low detection limit (0.13 μM). In addition, NSSN could achieve mitochondrial target detection of HClO in HeLa cells, also HClO could be visually detected in nude mice by NSSN. Thus NSSN is expected to be used in the early diagnosis of HClO.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
