Mitochondrial RNA turnover in the presence of cordycepin

Abstract

Cordycepin inhibits mitochondrial specific RNA synthesis. In contrast to the drug's effect on the nucleolus, no short RNA molecules are produced. After inhibition, prelabeled 12-S and 21-S molecules decay with a 3-h half-life. The mitochondrial 4-S RNA appears stable. The kinetics of decay of mitochondrial specific protein synthesis resembles that of mitochondrial RNA.