Abstract
We have isolated mouse and yeast nifS-like genes and characterized their products (mNfsl and yNFSI, respectively). We found that both proteins have an amino-terminal extension, which contains a typical mitochondrial targeting presequence, followed by the several characteristic features common to bacterial NifS proteins. By Western blot analysis, both the mNfsl and the yNFSI were found in the mitochondrial fraction. The mNfsl was shown to distribute in various mouse tissues. We also found that the yNFSI gene-disrupted mutant is lethal. These results suggest that both eukaryotic NifS-like proteins may play some significant roles in mitochondrial functions.
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