Abstract
1. 1. Phospholipid composition and the mitochondrial area of skeletal muscle of three species of mice were determined. 2. 2. Chemical, enzymatic and planimetric measurement demonstrated a direct relationship between the ability of an animal to withstand cold stress and the mitochondrial area. 3. 3. It was proposed that the ability to withstand severe cold stress is associated with an inherited sensitivity of muscle to thyroid hormone, that thyroid hormone is directly involved in non-shivering thermogenesis by the creation of an energy dependent mitochondrial swelling and indirectly involved by increasing mitochondrial area in cold resistant animals. 4. 4. Insulin may be involved in cold acclimation.
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