MITOCHONDRIAL FUNCTION AND OOCYTE QUALITY IMPROVED IN AN AGING MODEL BY INTRAOVARIAN ADMINISTRATION OF A COMBINATION OF STEM CELL-SECRETED- AND PLATELET-ENCLOSED GROWTH FACTORS

Abstract

Ovarian aging associates with a decline in the number and quality of oocytes, which is related to mitochondrial dysfunction and decreased mitochondrial DNA (mtDNA) copies, playing oxidative stress a crucial role in age-related infertility. New therapies based on Platelet-rich plasma (PRP) and stem cell (SC) secreted factors have been employed to improve ovarian function in several animal models of ovarian damage. However, how these treatments regulate ovarian mitochondrial function and oocyte quality has not yet been assessed in age-related infertility models mimicking different stages of women´s reproductive life.