Abstract
Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruvate transfer to the mitochondrial matrix, either by parasitic consumption and/or mitochondrial dysfunction. This can in turn lead to disturbance in water molecules’ ordering, diminished power, and coherence of the electromagnetic field. In tumors with the Warburg (reverse Warburg) effect, mitochondrial dysfunction affects cancer cells (fibroblasts associated with cancer cells), and the electromagnetic field generated by microtubules in cancer cells has low power (high power due to transport of energy-rich metabolites from fibroblasts), disturbed coherence, and a shifted frequency spectrum according to changed power. Therapeutic strategies restoring mitochondrial function may trigger apoptosis in treated cells; yet, before this step is performed, induction (inhibition) of pyruvate dehydrogenase kinases (phosphatases) may restore the cancer state. In tumor tissues with the reverse Warburg effect, Caveolin-1 levels should be restored and the transport of energy-rich metabolites interrupted to cancer cells. In both cancer phenotypes, achieving permanently reversed mitochondrial dysfunction with metabolic-modulating drugs may be an effective, specific anti-cancer strategy.
Highlights
A continuous energy supply to biological systems along with its transformation are among the essential processes for life
The thickness of the exclusion zone measured by the exclusion of positively charged particles increases with decreasing pH from the given value of pH (Figure 1). This phenomenon may explain differences between the apparent membrane potential measured by the uptake and retention of positively charged fluorescent dyes by mitochondria, and the true potential corresponding to mitochondrial oxidative metabolism
Response was elicited in all investigated cancers and the majority of T-lymphocytes taken from cancer patients did not adhere, whereas those from healthy women did. These results suggest that the mechanism of genome protection is disturbed by infection of the lactate dehydrogenase (LDH) virus, which was wrongly assumed to be silent and not harmful to the host
Summary
A continuous energy supply to biological systems along with its transformation are among the essential processes for life. Experimental evidence he provided demonstrated that cancer cells can obtain approximately the same amount of energy from fermentation as from respiration, whereas normal cells obtain greater levels of energy from oxidation than from fermentation [7,8] He proved that in cancer, the impairment of oxidative metabolism, which displays disturbance of pyruvate transfer, is conditioned by mitochondrial dysfunction, and intuitively described the consequences as a structure type defect which is explained as disturbance of water molecules’ ordering. He wrote that “...it is immaterial to the cells whether they obtain their energy from respiration or from fermentation...” and that “The adenosine triphosphate synthesized by respiration involves more structure than adenosine triphosphate synthesized by fermentation.”. The effect of the coherent electric oscillations on cellular processes remains poorly understood
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
